Here, we demonstrate that this COVID-19 prediction model has reasonable and consistent performance across multiple independent cohorts and that our attempt to improve upon this model did not result in improved predictions. Recently, it was shown that it is possible to predict COVID-19 cases using cross-sectional self-reported disease-related symptoms.

Franke LH Helix OpCo LLC, San Mateo, California, United States of America.Д®pidemiological and genetic studies on COVID-19 are currently hindered by inconsistent and limited testing policies to confirm SARS-CoV-2 infection.

Boezen HM Helix OpCo LLC, San Mateo, California, United States of America.

Deelen P Helix OpCo LLC, San Mateo, California, United States of America.

de Geus EJC Helix OpCo LLC, San Mateo, California, United States of America.

Washington NL Helix OpCo LLC, San Mateo, California, United States of America.

Lu JT Helix OpCo LLC, San Mateo, California, United States of America.

Lim YW Helix OpCo LLC, San Mateo, California, United States of America.

Ramirez JM Helix OpCo LLC, San Mateo, California, United States of America.

Wang X Helix OpCo LLC, San Mateo, California, United States of America.

Tanudjaja F Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

White S Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

Bolze A Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.

Riffle S MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

Porteous D Analytic and Translational Genetics Unit (ATGU), Massachusetts General Hospital, Boston, MA, United States of America.

Campbell A Broad Institute of MIT and Harvard, Cambridge, MA, United States of America.

Fawns-Ritchie C Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

Hayward C Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

Karjalainen J Department of Biological Psychology, FGB, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Ganna A Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Hottenga JJ Structural Computational Biology unit, EMBL, Heidelberg, Germany.

Bartels M Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Lopera-Maya EA Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Claringbould A Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Boulogne F Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Herkert JC Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Warmerdam RCA Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Vonk JM Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Ori APS Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Lanting P Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.van Blokland IV Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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